{"product_id":"cog133","title":"COG133, ApoE Mimetic Peptide","description":"\u003ch2 class=\"MsoNormal\"\u003e\u003cb\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 107%;\" lang=\"EN-IN\"\u003eCOG133 ApoE Mimetic Peptide – Neuroprotective \u0026amp; Anti-Inflammatory Agent\u003c\/span\u003e\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 107%; mso-bidi-font-weight: bold;\" lang=\"EN-IN\"\u003eCOG133\u003c\/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 107%;\" lang=\"EN-IN\"\u003e is a synthetic \u003cspan style=\"mso-bidi-font-weight: bold;\"\u003eApoE mimetic peptide\u003c\/span\u003e derived from the receptor-binding region of apolipoprotein E. It exhibits potent \u003cspan style=\"mso-bidi-font-weight: bold;\"\u003eanti-inflammatory\u003c\/span\u003e, \u003cspan style=\"mso-bidi-font-weight: bold;\"\u003eneuroprotective\u003c\/span\u003e, and \u003cspan style=\"mso-bidi-font-weight: bold;\"\u003ecognitive-supportive\u003c\/span\u003e effects, making it a key research peptide in neurodegenerative disease models and neuroimmune regulation.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 class=\"MsoNormal\"\u003e\u003cb\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 107%;\" lang=\"EN-IN\"\u003eCOG133 Peptide for Cognitive Health\u003c\/span\u003e\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp class=\"MsoNormal\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 107%;\" lang=\"EN-IN\"\u003eCOG133 acts via the \u003cspan style=\"mso-bidi-font-weight: bold;\"\u003elow-density lipoprotein receptor-related protein (LRP)\u003c\/span\u003e pathway and demonstrates promising applications in neurobiology, especially:\u003c\/span\u003e\u003c\/p\u003e\n\u003cul type=\"disc\" style=\"margin-top: 0in;\"\u003e\n\u003cli style=\"mso-list: l5 level1 lfo1; tab-stops: list .5in;\" class=\"MsoNormal\"\u003e\n\u003cspan style=\"font-size: 12.0pt; line-height: 107%; mso-bidi-font-weight: bold;\" lang=\"EN-IN\"\u003eSuppressing neuroinflammation\u003c\/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 107%;\" lang=\"EN-IN\"\u003e\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli style=\"mso-list: l5 level1 lfo1; tab-stops: list .5in;\" class=\"MsoNormal\"\u003e\n\u003cspan style=\"font-size: 12.0pt; line-height: 107%; mso-bidi-font-weight: bold;\" lang=\"EN-IN\"\u003eReducing demyelination\u003c\/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 107%;\" lang=\"EN-IN\"\u003e\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli style=\"mso-list: l5 level1 lfo1; tab-stops: list .5in;\" class=\"MsoNormal\"\u003e\n\u003cspan style=\"font-size: 12.0pt; line-height: 107%; mso-bidi-font-weight: bold;\" lang=\"EN-IN\"\u003eSupporting cognitive resilience\u003c\/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 107%;\" lang=\"EN-IN\"\u003e\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp class=\"MsoNormal\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 107%;\" lang=\"EN-IN\"\u003eIn studies on \u003cspan style=\"mso-bidi-font-weight: bold;\"\u003eexperimental autoimmune encephalomyelitis (EAE)\u003c\/span\u003e—a model of multiple sclerosis—COG133 significantly reduced clinical symptoms and spinal cord inflammation. This highlights its relevance for \u003cspan style=\"mso-bidi-font-weight: bold;\"\u003ecognitive health and neuroinflammatory research\u003c\/span\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 class=\"MsoNormal\"\u003e\u003cb\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 107%;\" lang=\"EN-IN\"\u003eCOG133 Anti-Inflammatory Effects\u003c\/span\u003e\u003c\/b\u003e\u003c\/h2\u003e\n\u003cul type=\"disc\" style=\"margin-top: 0in;\"\u003e\n\u003cli style=\"mso-list: l3 level1 lfo2; tab-stops: list .5in;\" class=\"MsoNormal\"\u003e\n\u003cspan style=\"font-size: 12.0pt; line-height: 107%; mso-bidi-font-weight: bold;\" lang=\"EN-IN\"\u003eModulates CNS inflammation\u003c\/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 107%;\" lang=\"EN-IN\"\u003e by targeting immune cell infiltration\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli style=\"mso-list: l3 level1 lfo2; tab-stops: list .5in;\" class=\"MsoNormal\"\u003e\n\u003cspan style=\"font-size: 12.0pt; line-height: 107%; mso-bidi-font-weight: bold;\" lang=\"EN-IN\"\u003eReduces pro-inflammatory cytokines\u003c\/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 107%;\" lang=\"EN-IN\"\u003e, helping preserve myelin integrity\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli style=\"mso-list: l3 level1 lfo2; tab-stops: list .5in;\" class=\"MsoNormal\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 107%;\" lang=\"EN-IN\"\u003eShows activity as a \u003cspan style=\"mso-bidi-font-weight: bold;\"\u003enon-competitive α7 nicotinic acetylcholine receptor antagonist\u003c\/span\u003e with an IC₅₀ of 445 nM\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"mso-list: l3 level1 lfo2; tab-stops: list .5in;\" class=\"MsoNormal\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 107%;\" lang=\"EN-IN\"\u003eUseful in inflammation-related neurological studies\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp class=\"MsoNormal\"\u003e\u003cb\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 107%;\" lang=\"EN-IN\"\u003eCOG133 vs COG112 Peptide Comparison\u003c\/span\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp class=\"MsoNormal\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 107%;\" lang=\"EN-IN\"\u003eWhile both are derived from \u003cspan style=\"mso-bidi-font-weight: bold;\"\u003eApoE peptides\u003c\/span\u003e, COG133 and COG112 differ in design and application:\u003c\/span\u003e\u003c\/p\u003e\n\u003cul type=\"disc\" style=\"margin-top: 0in;\"\u003e\n\u003cli style=\"mso-list: l1 level1 lfo3; tab-stops: list .5in;\" class=\"MsoNormal\"\u003e\n\u003cb\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 107%;\" lang=\"EN-IN\"\u003eCOG133\u003c\/span\u003e\u003c\/b\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 107%;\" lang=\"EN-IN\"\u003e: LRP-dependent pathway, potent anti-inflammatory and cognitive protection\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli style=\"mso-list: l1 level1 lfo3; tab-stops: list .5in;\" class=\"MsoNormal\"\u003e\n\u003cb\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 107%;\" lang=\"EN-IN\"\u003eCOG112\u003c\/span\u003e\u003c\/b\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 107%;\" lang=\"EN-IN\"\u003e: COG133 + penetratin sequence for improved BBB permeability\u003cbr\u003eFor applications not requiring direct CNS delivery, \u003cspan style=\"mso-bidi-font-weight: bold;\"\u003eCOG133 peptide\u003c\/span\u003e offers a cleaner, focused mechanism of action.\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp class=\"MsoNormal\"\u003e\u003cb\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 107%;\" lang=\"EN-IN\"\u003eTechnical Specifications\u003c\/span\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cul type=\"disc\" style=\"margin-top: 0in;\"\u003e\n\u003cli style=\"mso-list: l0 level1 lfo4; tab-stops: list .5in;\" class=\"MsoNormal\"\u003e\n\u003cb\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 107%;\" lang=\"EN-IN\"\u003ePeptide Name\u003c\/span\u003e\u003c\/b\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 107%;\" lang=\"EN-IN\"\u003e: COG133\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli style=\"mso-list: l0 level1 lfo4; tab-stops: list .5in;\" class=\"MsoNormal\"\u003e\n\u003cb\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 107%;\" lang=\"EN-IN\"\u003eSequence\u003c\/span\u003e\u003c\/b\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 107%;\" lang=\"EN-IN\"\u003e: Ac-LRVRLASHLRKLRKRLL-NH₂\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli style=\"mso-list: l0 level1 lfo4; tab-stops: list .5in;\" class=\"MsoNormal\"\u003e\n\u003cb\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 107%;\" lang=\"EN-IN\"\u003eMolecular Formula\u003c\/span\u003e\u003c\/b\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 107%;\" lang=\"EN-IN\"\u003e: C₉₇H₁₈₁N₃₇O₁₉\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli style=\"mso-list: l0 level1 lfo4; tab-stops: list .5in;\" class=\"MsoNormal\"\u003e\n\u003cb\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 107%;\" lang=\"EN-IN\"\u003eMolecular Weight\u003c\/span\u003e\u003c\/b\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 107%;\" lang=\"EN-IN\"\u003e: 2169.73 g\/mol\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli style=\"mso-list: l0 level1 lfo4; tab-stops: list .5in;\" class=\"MsoNormal\"\u003e\n\u003cb\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 107%;\" lang=\"EN-IN\"\u003eCAS Number\u003c\/span\u003e\u003c\/b\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 107%;\" lang=\"EN-IN\"\u003e: 514200-66-9\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli style=\"mso-list: l0 level1 lfo4; tab-stops: list .5in;\" class=\"MsoNormal\"\u003e\n\u003cb\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 107%;\" lang=\"EN-IN\"\u003ePubChem CID\u003c\/span\u003e\u003c\/b\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 107%;\" lang=\"EN-IN\"\u003e: 16201427\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli style=\"mso-list: l0 level1 lfo4; tab-stops: list .5in;\" class=\"MsoNormal\"\u003e\n\u003cb\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 107%;\" lang=\"EN-IN\"\u003ePurity\u003c\/span\u003e\u003c\/b\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 107%;\" lang=\"EN-IN\"\u003e: ≥95% (HPLC-verified)\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli style=\"mso-list: l0 level1 lfo4; tab-stops: list .5in;\" class=\"MsoNormal\"\u003e\n\u003cb\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 107%;\" lang=\"EN-IN\"\u003eStorage\u003c\/span\u003e\u003c\/b\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 107%;\" lang=\"EN-IN\"\u003e: –20°C (long-term)\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp class=\"MsoNormal\"\u003e\u003cb\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 107%;\" lang=\"EN-IN\"\u003eApplications\u003c\/span\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cul type=\"disc\" style=\"margin-top: 0in;\"\u003e\n\u003cli style=\"mso-list: l2 level1 lfo5; tab-stops: list .5in;\" class=\"MsoNormal\"\u003e\n\u003cspan style=\"font-size: 12.0pt; line-height: 107%; mso-bidi-font-weight: bold;\" lang=\"EN-IN\"\u003eNeuroinflammation research\u003c\/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 107%;\" lang=\"EN-IN\"\u003e\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli style=\"mso-list: l2 level1 lfo5; tab-stops: list .5in;\" class=\"MsoNormal\"\u003e\n\u003cspan style=\"font-size: 12.0pt; line-height: 107%; mso-bidi-font-weight: bold;\" lang=\"EN-IN\"\u003eMultiple sclerosis models (EAE)\u003c\/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 107%;\" lang=\"EN-IN\"\u003e\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli style=\"mso-list: l2 level1 lfo5; tab-stops: list .5in;\" class=\"MsoNormal\"\u003e\n\u003cspan style=\"font-size: 12.0pt; line-height: 107%; mso-bidi-font-weight: bold;\" lang=\"EN-IN\"\u003eCognitive impairment and memory studies\u003c\/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 107%;\" lang=\"EN-IN\"\u003e\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli style=\"mso-list: l2 level1 lfo5; tab-stops: list .5in;\" class=\"MsoNormal\"\u003e\n\u003cspan style=\"font-size: 12.0pt; line-height: 107%; mso-bidi-font-weight: bold;\" lang=\"EN-IN\"\u003eApoE receptor pathway investigations\u003c\/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 107%;\" lang=\"EN-IN\"\u003e\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli style=\"mso-list: l2 level1 lfo5; tab-stops: list .5in;\" class=\"MsoNormal\"\u003e\n\u003cspan style=\"font-size: 12.0pt; line-height: 107%; mso-bidi-font-weight: bold;\" lang=\"EN-IN\"\u003eAnti-inflammatory peptide drug development\u003c\/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 107%;\" lang=\"EN-IN\"\u003e\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp class=\"MsoNormal\"\u003e\u003cb\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 107%;\" lang=\"EN-IN\"\u003eBuy COG133 Peptide Online\u003c\/span\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp class=\"MsoNormal\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 107%;\" lang=\"EN-IN\"\u003eLooking for \u003cspan style=\"mso-bidi-font-weight: bold;\"\u003ehigh-purity COG133 ApoE mimetic peptide\u003c\/span\u003e? We offer lab-tested, research-grade material ready for:\u003c\/span\u003e\u003c\/p\u003e\n\u003cul type=\"disc\" style=\"margin-top: 0in;\"\u003e\n\u003cli style=\"mso-list: l4 level1 lfo6; tab-stops: list .5in;\" class=\"MsoNormal\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 107%;\" lang=\"EN-IN\"\u003eAcademic and pharmaceutical R\u0026amp;D\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"mso-list: l4 level1 lfo6; tab-stops: list .5in;\" class=\"MsoNormal\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 107%;\" lang=\"EN-IN\"\u003ePreclinical neuroimmune and cognitive health research\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"mso-list: l4 level1 lfo6; tab-stops: list .5in;\" class=\"MsoNormal\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 107%;\" lang=\"EN-IN\"\u003eIn vitro and in vivo experiments\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp class=\"MsoNormal\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 107%; mso-bidi-font-weight: bold;\" lang=\"EN-IN\"\u003eBuy COG133 peptide online\u003c\/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 107%;\" lang=\"EN-IN\"\u003e today and support your next breakthrough in peptide-based neuroscience.\u003c\/span\u003e\u003c\/p\u003e","brand":"QUALITIDE","offers":[{"title":"10 mg","offer_id":42005821751405,"sku":"QT-2006-10MG","price":499.0,"currency_code":"USD","in_stock":true},{"title":"2 mg","offer_id":42005865365613,"sku":"QT-2006-2MG","price":148.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0605\/4019\/0829\/files\/product-4-2mg.png?v=1768924182","url":"https:\/\/sunig0-dr.myshopify.com\/products\/cog133","provider":"QUALITIDE","version":"1.0","type":"link"}